What is it?

MOTS-C (Mitochondrial Open Reading Frame of the Twelve S c) is a peptide encoded within the mitochondrial genome—making it unique among peptides as one of the few that originates from mitochondrial DNA rather than nuclear DNA. Discovered in 2015, it acts as a signaling molecule that regulates metabolic processes throughout the body. MOTS-C has generated significant interest in longevity and performance research due to its role in exercise adaptation and metabolic health.

Who It's For?

•Individuals feeling their body isn't responding to exercise like it used to

•Those seeking long-term metabolic optimization

•Athletes looking to enhance endurance and performance

•Adults interested in healthy aging and longevity

•People with metabolic concerns looking for cellular-level support

what does it do?

•Enhances exercise capacity and endurance

•Supports healthy body composition

•Promotes mitochondrial health and function

•May support healthy aging at the cellular level

•Helps the body adapt to physical stress more effectively

How does it work?

MOTS-C works as a mitochondrial signaling molecule with system-wide effects:

•AMPK activation — Stimulates the master metabolic regulator, mimicking some effects of exercise

•Glucose regulation — Improves how cells take up and use glucose for energy

•Muscle metabolism — Enhances the muscle's ability to adapt to exercise stress

•Mitochondrial communication — Signals between mitochondria and the nucleus to optimize cellular function

Typically administered via subcutaneous injection 2-3 times weekly. Best used as part of an active lifestyle to maximize its exercise-mimetic and performance-enhancing effects.

What to expect

Short Term (Weeks 2-4)

•Improved exercise tolerance and endurance

•Better energy levels during workouts

•Enhanced recovery between training sessions

•More stable energy throughout the day

Long Term (Months 2-4+)

•Improved body composition

•Enhanced metabolic markers

•Greater exercise adaptations

•Sustained performance improvements

best paired with

•NAD+ — For comprehensive mitochondrial and cellular energy support

•BPC-157/TB-500 — For enhanced recovery from intense training

•Sermorelin — For complementary body composition and recovery benefits

•Regular exercise — Essential—MOTS-C works best with consistent physical activity

Ready to Enhance Your Performance?

Schedule a consultation to discuss whether the MOTS-C is right for your goals.

MOTS-C